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Satoshi Koinuma, Takeshi Asakawa, Mamoru Nagano, Keiichi Furukawa, Mitsugu Sujino, Koh-Hei Masumoto, Yoshihiro Nakajima, Seiichi Hashimoto, Kazuhiro Yagita and Yasufumi Shigeyoshi Regional circadian period difference in the suprachiasmatic nucleus of the mammalian circadian center European Journal of Neuroscience 38

Article first published online: 21 JUL 2013 | DOI: 10.1111/ejn.12308

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We disrupted the intercellular coupling among oscillating neurons in the suprachiasmatic nucleus (SCN), the mammalian circadian center. The treatment by forskolin divided the SCN into two regions: A region with periods shorter than 24 h (SPR) and another with periods longer than 24 h (LPR). The SPR corresponded well with the region in which the SCN phase wave is generated. A numerical simulation suggested that the coexistance of SPR and LPR generates the phase wave in the SCN.

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