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Julie S. Pendergast, Kevin D. Niswender and Shin Yamazaki The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice European Journal of Neuroscience 38

Article first published online: 21 JUL 2013 | DOI: 10.1111/ejn.12309

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The suprachiasmatic nucleus (SCN) is the master pacemaker in the mammalian circadian system. When methamphetamine is present, locomotor activity is the integrated output of the SCN and the enigmatic methamphetamine-sensitive circadian oscillator (MASCO). In this study, we found that the in vivo relationship between the SCN and MASCO is altered by mutation of the Period genes and by exposure to variable lighting conditions and we propose a working model of this integrative oscillator network.

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