J. R. Casanova, M. Nishimura, J. Le, T. T. Lam and J. W. Swann Rapid hippocampal network adaptation to recurring synchronous activity – a role for calcineurin European Journal of Neuroscience 38
Developing hippocampal networks were found to rapidly adapt to recurring synchronised activity. Reductions in network burst duration, frequency of spontaneous EPSCs, expression of glutamatergic synaptic proteins and dendritic branching of pyramidal neurons were observed after 4 h of increased activity. Calcineurin inhibitors prevented these effects. Results add to a growing appreciation of how altered calcium signaling, resulting from abnormal activity, impacts hippocampal development.
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