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Judyta K. Juranek, Matthew S. Geddis, Rosa Rosario and Ann Marie Schmidt Impaired slow axonal transport in diabetic peripheral nerve is independent of RAGE European Journal of Neuroscience 38

Article first published online: 14 AUG 2013 | DOI: 10.1111/ejn.12333

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Axonal transport of Neurofilament and mDia1 actin binding, RAGE interacting protein is impaired 3 and 6 h after the crush in the diabetic peripheral nerve, but independent of RAGE. Protein glycation is likely contributing to axonal transport impairment. We speculated that axonal transport changes in the diabetic nerve result at least in part from diabetes – evoked glycation and affect neurofilament and actin binding proteins early in the course of the disease.

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