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Damian P. Bright and Trevor G. Smart Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus European Journal of Neuroscience 38

Version of Record online: 16 SEP 2013 | DOI: 10.1111/ejn.12352

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PKC activation causes a down-regulation in tonic GABAA receptor-mediated inhibition in hippocampal dentate gyrus granule cells and thalamic dorsal lateral geniculate relay neurons. These findings are corroborated by studying recombinant α4β2δ receptors, which demonstrate a similar inhibition of receptor function, which involves the loss of surface receptors. PKC-mediated phosphorylation is considered an important physiological regulator of tonic GABA inhibition.

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