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Fabien Delaere, Hideo Akaoka, Filipe De Vadder, Adeline Duchampt and Gilles Mithieux Portal glucose influences the sensory, cortical and reward systems in rats European Journal of Neuroscience 38

Article first published online: 8 SEP 2013 | DOI: 10.1111/ejn.12354

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Intestinal gluconeogenesis and portal glucose (PoG) sensing mediate the satiety effect of protein-enriched diets (PED). In addition to brain regions classically involved in energy homeostasis (parabrachial nucleus, hypothalamus), PoG might also influence food preference and reward via multiple targets including the olfactory bulb, amygdala, nucleus accumbens and orbitofrontal cortex. PED induce similar effects in the hypothalamus and olfactory bulb, while diets rich in fat and sucrose do not.

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