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Romain Le Cozannet, Athina Markou and Ronald Kuczenski Extended-access, but not limited-access, methamphetamine self-administration induces behavioral and nucleus accumbens dopamine response changes in rats European Journal of Neuroscience 38

Version of Record online: 23 SEP 2013 | DOI: 10.1111/ejn.12361

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In the extended but not in limited access groups, the microdialysis results revealed tolerance to the methamphetamine-induced increases in extracellular dopamine in the nucleus accumbens, which may be associated with the increased lever pressing (higher methamphetamine intake), and drug seeking observed during the first hour of drug exposure, and may result in more severe consequences in other structures responsible for the behavioral deficits observed.

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