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Christopher C. Leonardo, Megha Agrawal, Nilendra Singh, J. Russell Moore, Shyam Biswal and Sylvain Doré Oral administration of the flavanol (−)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway European Journal of Neuroscience 38

Article first published online: 23 SEP 2013 | DOI: 10.1111/ejn.12362

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Using two model systems of ischemia (oxygen glucose deprivation, OGD, and permanent middle cerebral artery occlusion, pdMCAO), we demonstrate epicatechin protection through activation of Nrf2. Epicatechin protected primary neurons from OGD by increasing neuronal viability and reducing protein oxidation. Nrf2 activation in pdMCAO also extends the benefits to improved performance on a complex sensorimotor task, highlighting the potential of flavan-3-ols in minimizing subsequent stroke injury.

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