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Linda Block, Per Jörneberg, Ulrika Björklund, Anna Westerlund, Björn Biber and Elisabeth Hansson Ultralow concentrations of bupivacaine exert anti-inflammatory effects on inflammation-reactive astrocytes European Journal of Neuroscience 38

Version of Record online: 15 SEP 2013 | DOI: 10.1111/ejn.12364

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Ultralow concentrations of bupivacaine interacts with the opioid-, 5-HT-, and glutamate- receptor systems and restore Ca2+ transients/oscillations to physiological levels in astrocytes. Ultralow concentrations of bupivacaine prevent IL-1β secretion in inflammation-reactive astrocytes.

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