Tomokazu Tsurugizawa, Yoshihito Nogusa, Yumi Ando and Hisayuki Uneyama Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate European Journal of Neuroscience 38
Awake functional MRI was used to investigate the brain response to the gut capsaicin and capsiate in mice. The BOLD signals in the medial preoptic area (mPOA) and ventromedial hypothalamus (VMH) were increased by intragastric infusion of capsaicin and capsiate, but those in the periaqueductal grey (PAG) were increased by capsaicin, not by capsiate. These responses were not observed in TRPV1 KO mice, indicating both capsaicin and capsiate activated these brain regions through TRPV1 receptors.
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