Zhi-ling Li, Luo Xu, Xiang-rong Sun, Fei-fei Guo, Yan-ling Gong and Sheng-li Gao Central nesfatin-1 influences the excitability of ghrelin-responsive gastric distension neurons in the arcuate nucleus and reduces gastric motility in rats European Journal of Neuroscience 38
An involvement of hypothalamic Arc nesfatin-1 in the regulation of gastric motility has remained elusive. Here we found exogenous nesfatin-1 could play a role in the regulation of the neuronal firing activity in the Arc as well as gastric motility via the melanocortin pathway, and PVN may participate in the central mediation of the effects. This study provides a new guide for diagnosis of gastrointestinal diseases and potential neural mechanisms.
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