E. Waddington Lamont, J. Bruton, I. D. Blum and A. Abizaid Ghrelin receptor-knockout mice display alterations in circadian rhythms of activity and feeding under constant lighting conditions European Journal of Neuroscience 39
Ghrelin is an orexigenic stomach hormone, and may also be a modulator of the circadian system. In constant darkness, GHSR KO mice required more days to develop a high level of food anticipatory activity, but, in constant light, showed greater activity overall, and greater activity in anticipation of a scheduled meal. These results suggest that the ghrelin receptor plays a role in modulating the activity of the circadian system, but does so through mechanisms that remain to be determined.
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