Akiyo Natsubori, Ken-ichi Honma and Sato Honma Dual regulation of clock gene Per2 expression in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats European Journal of Neuroscience 39
Periodic administration of methamphetamine containing water to rats induced an oscillation (MAO) independent of the circadian pacemaker in the suprachiasmatic nucleus (SCN). Bilateral SCN lesions accelerated MAO-induced changes of the circadian Per2 expression rhythms in several areas of brain dopaminergic system, indicating that MAO and SCN pacemaker regulate coordinately the extra-SCN circadian oscillators in these areas. Differential coordination suggests that they are the components of MAO.
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