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Akiyo Natsubori, Ken-ichi Honma and Sato Honma Dual regulation of clock gene Per2 expression in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats European Journal of Neuroscience 39

Version of Record online: 25 OCT 2013 | DOI: 10.1111/ejn.12400

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Periodic administration of methamphetamine containing water to rats induced an oscillation (MAO) independent of the circadian pacemaker in the suprachiasmatic nucleus (SCN). Bilateral SCN lesions accelerated MAO-induced changes of the circadian Per2 expression rhythms in several areas of brain dopaminergic system, indicating that MAO and SCN pacemaker regulate coordinately the extra-SCN circadian oscillators in these areas. Differential coordination suggests that they are the components of MAO.

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