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Dan Madularu, Waqqas M. Shams and Wayne G. Brake Estrogen potentiates the behavioral and nucleus accumbens dopamine response to continuous haloperidol treatment in female rats European Journal of Neuroscience 39

Article first published online: 25 OCT 2013 | DOI: 10.1111/ejn.12401

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Haloperidol treatment along with high, but not low, estradiol replacement was effective in reducing amphetamine-induced locomotor activity in sensitized rats. High estradiol treatment also augmented the effects of chronic haloperidol in reducing dopaminergic release in sensitized rats. These data suggest that estradiol levels affect both the behavioral and dopamine responses to chronic antipsychotic treatment.

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