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Xiaojing Dai, Hirohide Iwasaki, Masahiko Watanabe and Shigeo Okabe Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression European Journal of Neuroscience 39

Article first published online: 15 NOV 2013 | DOI: 10.1111/ejn.12413

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Dlx1 is expressed in mouse hippocampal interneurons. Overexpression of Dlx1 in excitatory pyramidal neurons reduces the number of dendrites dramatically and the resultant morphology of neuron becomes similar to that of interneurons. Conversely, downregulation of Dlx1 increases the number of dendrites in interneurons. These results suggest the role of Dlx1 as an endogenous regulator of dendrite morphogenesis in interneurons.

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