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Kaid Johar, Anusha Priya and Margaret T. T. Wong-Riley Regulation of Na+/K+-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons European Journal of Neuroscience 39

Article first published online: 12 NOV 2013 | DOI: 10.1111/ejn.12415

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Na+/K+-ATPase, a major energy consumer in neurons, is regulated by the neuron-specific specificity protein 4 (Sp4), with minor contributions from Sp1 and Sp3. Sp4 positively regulates the expression of Atp1a1, Atp1a3, and Atp1b1 subunit genes of Na+/K+-ATPase. As Sp4 is recently found by us to also regulate cytochrome c oxidase subunit genes and critical glutamate receptor subunit genes, it mediates the coupling of energy consumption, energy generation, and neuronal activity in neurons.

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