Christopher A. Brown, Wael El-Deredy and Anthony K. P. Jones When the brain expects pain: common neural responses to pain anticipation are related to clinical pain and distress in fibromyalgia and osteoarthritis European Journal of Neuroscience 39
Supra-spinal processes in humans can exert a top-down enhancing effect on nociceptive processing in the brain and spinal cord. Studies have begun to suggest such influences occur in conditions such as fibromyalgia (FM), but it is not clear if this is unique to FM pain or common to other forms of chronic pain, such as that associated with osteoarthritis (OA).
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