Stephen B. G. Abbott, Benjamin B. Holloway, Kenneth E. Viar and Patrice G. Guyenet Vesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice in vivo European Journal of Neuroscience 39
Catecholaminergic neurons of the rostral ventrolateral medulla (RVLM-CA neurons, viz. C1 neurons) contribute to the sympathetic, parasympathetic and neuroendocrine responses elicited by physical stressors such as hypotension, hypoxia, hypoglycemia and infection. Most RVLM-CA neurons express vesicular glutamate transporter 2 (VGLUT2) and may use glutamate as a ionotropic transmitter but the importance of this mode of transmission in vivo is uncertain.
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