Nicole A. Crowley, Patrick A. Cody, Margaret I. Davis, David M. Lovinger and Yolanda Mateo Chronic methylphenidate exposure during adolescence reduces striatal synaptic responses to ethanol European Journal of Neuroscience 39
Administration of therapeutically relevant doses of methylphenidate, a psychostimulant used as cognitive enhancer, during development can have long-term effects on synaptic plasticity in forebrain regions targeted by dopamine. Chronic peri-adolescence exposure to methylphenidate modifies dopamine release dynamics, synaptic plasticity, and ethanol-mediated plasticity. These enduring neural adaptations are likely to underlie neural and behavioral responses to ethanol administration in adulthood.
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