E-mail

E-mail a Wiley Online Library Link

Xavier Nicol and Patricia Gaspar Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases European Journal of Neuroscience 39

Article first published online: 15 MAR 2014 | DOI: 10.1111/ejn.12543

Thumbnail image of graphical abstract

How cAMP signals are precisely controlled in time and space to produce such a broad range of developmental effects remains unknown, but one of the key elements in this process lies in the regulation of the enzymes that produce cAMP, the adenylate cyclases (ACs). AC mutants that are defective for a subset of the calcium sensitive isoforms, namely AC1, AC3 and AC10, have defects in neural wiring in main developmental model systems such as the barrel cortex, the visual pathways, the olfactory system, and the corticospinal tract. Studies over the last ten years emphasized the role of calcium-stimulated adenylate cyclases during late stages of neural circuit wiring suggesting that a main function of these ACs during development would be to act as integrators of neural activity and axon guidance molecules.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH