Xavier Nicol and Patricia Gaspar Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases European Journal of Neuroscience 39
How cAMP signals are precisely controlled in time and space to produce such a broad range of developmental effects remains unknown, but one of the key elements in this process lies in the regulation of the enzymes that produce cAMP, the adenylate cyclases (ACs). AC mutants that are defective for a subset of the calcium sensitive isoforms, namely AC1, AC3 and AC10, have defects in neural wiring in main developmental model systems such as the barrel cortex, the visual pathways, the olfactory system, and the corticospinal tract. Studies over the last ten years emphasized the role of calcium-stimulated adenylate cyclases during late stages of neural circuit wiring suggesting that a main function of these ACs during development would be to act as integrators of neural activity and axon guidance molecules.
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