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Kamini Rakkar, Kirtiman Srivastava and Ulvi Bayraktutan Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase European Journal of Neuroscience 39

Version of Record online: 20 MAR 2014 | DOI: 10.1111/ejn.12552

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Disruption of blood-brain barrier (BBB) continues to be the leading cause of mortality after an ischemic stroke. Exposing the main cellular component of human BBB, namely brain microvascular endothelial cells (HBMEC) to OGD±R, this study shows that attenuation of urokinase activity (uPA) protects the integrity of an in vitro model of human BBB against ischemia-evoked damage through a cascade of mechanisms involving concomitant suppression of oxidative stress and matrix metalloprotinases.

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