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Venugopal R. Venna, Jun Li, Matthew D. Hammond, Nickolas S. Mancini and Louise D. McCullough Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke European Journal of Neuroscience 39

Article first published online: 21 MAR 2014 | DOI: 10.1111/ejn.12556

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Chronic metformin treatment improves post-stroke functional recovery in mice subjected to experimental stroke. This recovery occurred in parallel with enhanced VEGF expression and reduced glial scar formation. There was a significant increase in neovascularization of peri-ischemic tissue. Using genetically engineered AMPK α2 knock-out mice we confirmed that the beneficial effects of metformin are mediated via AMPK signaling.

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