Robert C. Wolf, Fabio Sambataro, Nenad Vasic, Eva-Maria Baldas, Iris Ratheiser, Georg Bernhard Landwehrmeyer, Malte S. Depping, Philipp A. Thomann, Reiner Sprengelmeyer, Sigurd D. Süssmuth and Michael Orth Visual system integrity and cognition in early Huntington's disease European Journal of Neuroscience 40
Version of Record online: 3 APR 2014 | DOI: 10.1111/ejn.12575
We confirm previous findings indicative of widespread posterior cortical atrophy in early manifest HD. Despite this volume loss changes of visual system activity at rest are limited to the left fusiform cortex, and the majority of posterior cortical volume changes do not substantially affect visual system activity. The relationship between fusiform cortical activity changes and visuomotor performance indicates behaviorally relevant contributions of extrastriate visual areas to cognition.
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