Ben Coomber, Joel I. Berger, Victoria L. Kowalkowski, Trevor M. Shackleton, Alan R. Palmer and Mark N. Wallace Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig European Journal of Neuroscience 40
Tinnitus was induced in guinea pigs by exposing animals to loud noise, behaviourally identified, and compared with a series of neural markers. Spontaneous neuronal firing in the inferior colliculus increased after noise exposure but this did not correlate with behavioural tinnitus. Auditory brainstem response latencies were reduced in animals with tinnitus, while asymmetric nitric oxide synthase staining was identified in animals with tinnitus.
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