Diane H. Oh, Diamanda Rigas, Ara Cho and Jefferson Y. Chan Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability FEBS Journal 279
Transcription factor Nrf1 regulates cellular stress response. In this study, we showed that loss of Nrf1 function leads to increased micronuclei, formation of abnormal nuclei, and aneuploidy. These defects were associated with decreased expression of various genes encoding kinetochore and mitotic checkpoint proteins suggesting that Nrf1 may serve a function in maintaining genomic integrity.
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