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Raimo Mikkola, Maria A. Andersson, László Kredics, Pavel A. Grigoriev, Nina Sundell and Mirja S. Salkinoja-Salonen 20-Residue and 11-residue peptaibols from the fungus Trichoderma longibrachiatum are synergistic in forming Na+/K+-permeable channels and adverse action towards mammalian cells FEBS Journal 279

Article first published online: 16 OCT 2012 | DOI: 10.1111/febs.12010

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The T. longibrachiatum strains produced 11- and 20-residue peptaibols (green and blue) forming Na+/K+ permeable ion-channels in lipid bilayer with synergistic properties. The combined 11- and 20-residue peptaibols generated channels that remained in an open state for a longer time than those formed by either peptaibol alone. As a result the two peptaibols were synergistically toxic toward mammalian cells.

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