Raimo Mikkola, Maria A. Andersson, László Kredics, Pavel A. Grigoriev, Nina Sundell and Mirja S. Salkinoja-Salonen 20-Residue and 11-residue peptaibols from the fungus Trichoderma longibrachiatum are synergistic in forming Na+/K+-permeable channels and adverse action towards mammalian cells FEBS Journal 279
The T. longibrachiatum strains produced 11- and 20-residue peptaibols (green and blue) forming Na+/K+ permeable ion-channels in lipid bilayer with synergistic properties. The combined 11- and 20-residue peptaibols generated channels that remained in an open state for a longer time than those formed by either peptaibol alone. As a result the two peptaibols were synergistically toxic toward mammalian cells.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf