Christian E. H. Schmelzer, Michael C. Jung, Johannes Wohlrab, Reinhard H. H. Neubert and Andrea Heinz Does human leukocyte elastase degrade intact skin elastin? The FEBS Journal 279
Elastin is a vital and extremely durable protein of the extracellular matrix of vertebrates and provides elasticity to many tissues. Here, we report that human leukocyte elastase, an enzyme often proposed to be important in elastin catabolism at inflammatory sites did not degrade intact skin elastin, but hydrolyzed elastin derived from the skin of old people.
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