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Xiao-Pu He, Yun Shao, Xiao-Lin Li, Wei Xu, Guo-Sheng Chen, Huan-Huan Sun, Hai-Chen Xu, Xian Xu, Dan Tang, Xi-Feng Zheng, Yi-Ping Xue, Guo-Chang Huang and Wei-Hao Sun Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth The FEBS Journal 279

Version of Record online: 22 OCT 2012 | DOI: 10.1111/febs.12013

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COX-2 plays important role in the carcinogenesis and progression of gastric cancer. We found an inverse correlation between miR-101 and COX-2 expression in gastric cancer specimens and cell lines. Overexpression of miR-101 inhibited cell proliferation in vitro and tumor growth in vivo, suggesting that miR-101 may function as a tumor suppressor in gastric cancer, with COX-2 as a direct target.

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