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Matthew A. Smith, Andrea Rentmeister, Christopher D. Snow, Timothy Wu, Mary F. Farrow, Florence Mingardon and Frances H. Arnold A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination FEBS Journal 279

Article first published online: 9 NOV 2012 | DOI: 10.1111/febs.12032

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We recombine the catalytic domains of three family 48 bacterial cellulases (Cel48, EC 3.2.1.176) to create a diverse collection of chimeric cellulases having an average of 106 mutations from the closest native enzyme. Thermostable and catalytically active chimeric family 48 cellulases can be accurately predicted using a simple sequence-function model trained on data from a small sample of chimeras

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