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Nishma Chauhan, Jaswir Basran, Sara A. Rafice, Igor Efimov, Elizabeth S. Millett, Christopher G. Mowat, Peter C. E. Moody, Sandeep Handa and Emma L. Raven How is the distal pocket of a heme protein optimized for binding of tryptophan? FEBS Journal 279

Article first published online: 22 NOV 2012 | DOI: 10.1111/febs.12036

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How is the distal pocket of a heme protein optimised for binding of tryptophan? Binding of tryptophan is a particular speciality of the distal active sites of the tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase catalytic enzymes. Using mutagenesis, we probe the functional role various active site residues in both human enzymes and make comparisons with other related heme enzymes

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