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Yaping Wang, Hongye Fan, Guangfeng Zhao, Dan Liu, Leilei Du, Zhiqun Wang, Yali Hu and Yayi Hou miR-16 inhibits the proliferation and angiogenesis-regulating potential of mesenchymal stem cells in severe pre-eclampsia The FEBS Journal 279

Version of Record online: 22 NOV 2012 | DOI: 10.1111/febs.12037

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The differential expression of miRNAs in decidua-derived mesenchymal stem cells from normal and pre-eclampsia groups was analysed using microarrays and bioinformatics. Over-expressed miR-16 inhibited the proliferation and migration of dMSCs and induced cell cycle arrest by targeting CCNE1. miR-16-over-expressed dMSCs reduced the ability of HUVEC to form blood vessels and the migration of the trophoblast cells

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