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Mohd Akif, Geoffrey Masuyer, Richard J. Bingham, Edward D. Sturrock, R. Elwyn Isaac and K. Ravi Acharya Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster FEBS Journal 279

Article first published online: 22 NOV 2012 | DOI: 10.1111/febs.12038

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Human somatic angiotensin-I converting enzyme (ACE) is the principal component of the renin angiotensin-aldosterone system that regulates blood pressure, and is therefore an important therapeutic target. The structures of AnCE (Drosophila melanogaster homologue of ACE) co-crystallised with mammalian peptide substrates are reported here. This study improves our understanding of the mechanism by which peptides inhibit this family of enzymes


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