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Luciana O. Almeida, Renata N. Goto, Cezar R. Pestana, Sérgio A. Uyemura, Silvio Gutkind, Carlos Curti and Andréia M. Leopoldino SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates The FEBS Journal 279

Version of Record online: 23 NOV 2012 | DOI: 10.1111/febs.12047

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Aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase pi 1 (GSTP1) are important enzymes for cellular detoxification and low efficiency favors oral cancer. SET protein, a histone acetylation modulator accumulated in HNSCC, decreased ALDH2 and GSTP1 mRNA levels and protein activities, increased DNA damage in association with TP53 up-regulation and BRCA2 recruitment, promoting DDR impairment

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