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Dibyendu Chakraborty, Karla K. Rodgers, Shannon M. Conley and Muna I. Naash Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS The FEBS Journal 280

Version of Record online: 22 NOV 2012 | DOI: 10.1111/febs.12055

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The second intradiscal loop of the photoreceptor tetraspanin RDS contains mutations which cause widely varying blinding phenotypes. Here we conduct circular dichroism studies of this protein region to understand the effects disease-causing mutations have on the secondary protein structure. The majority of examined mutations cause decreases in the α-helical content of this loop but no change in thermal stability

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