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Rym Tlatli, Hervé Nozach, Guillaume Collet, Fabrice Beau, Laura Vera, Enrico Stura, Vincent Dive and Philippe Cuniasse Grafting of functional motifs onto protein scaffolds identified by PDB screening – an efficient route to design optimizable protein binders The FEBS Journal 280

Version of Record online: 29 NOV 2012 | DOI: 10.1111/febs.12056

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Artificial miniproteins targeting catalytic sites of matrix metalloproteinases (MMPs) were designed by grafting a functional motif on miniprotein scaffolds obtained by screening the Protein Data Bank (PDB) using the STAMPS software. This application illustrates the good yield of the method, as all designs were capable to bind the targets with affinities ranging from 450 nm and 450 μm.

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