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Mark J. Quinton-Tulloch, Frank J. Bruggeman, Jacky L. Snoep and Hans V. Westerhoff Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico FEBS Journal 280

Article first published online: 7 DEC 2012 | DOI: 10.1111/febs.12057

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We describe a quantitative method for defining the fragility and robustness of system fluxes to perturbations, equating fragility with control as defined in metabolic control analysis. Application of this methodology to mathematical models of metabolic pathways highlights the non-intuitive nature of the interplay between fragility and robustness and the need for a dynamic network understanding.

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