Ting Wang, Lei Zhao, Ye Yang, Hua Tian, Wen-Hao Suo, Min Yan and Guo-Hui Fu EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells FEBS Journal 280
Gastrin upregulates the expression of anion exchanger (AE)2 in gastric cancer cells. The upregulated species of AE2 mRNA originates from the upstream promoter of AE2 gene, which provides the binding site for EGR1 and SP1. Overexpression or knockdown of EGR1 increased or decreased the expression of AE2. Our data link a novel signal pathway involved in gastrin-stimulated AE2 expression.
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