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Daniel C. Palm, Johann M. Rohwer and Jan-Hendrik S. Hofmeyr Regulation of glycogen synthase from mammalian skeletal muscle – a unifying view of allosteric and covalent regulation The FEBS Journal 280

Version of Record online: 6 DEC 2012 | DOI: 10.1111/febs.12059

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Despite the chemical differences in allosteric and covalent modification of mammalian skeletal muscle glycogen synthase, results from enzyme kinetics, crystal structure data, and site-directed mutagenesis studies suggest that these two regulatory mechanisms behave and interact in a manner characteristic of classic Monod-Wyman-Changeux heterotropic effectors. This allows for a succinct description of glycogen synthase kinetics despite its numerous phosphorylation states.

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