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Ewa A. Grzybowska, Valery Zayat, Ryszard Konopiński, Alicja Trębińska, Maria Szwarc, Elżbieta Sarnowska, Ewelina Macech, Jarosław Korczyński, Anna Knapp and Janusz A. Siedlecki HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing The FEBS Journal 280

Version of Record online: 11 DEC 2012 | DOI: 10.1111/febs.12066

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Multifunctional HAX-1 protein is known to bind mRNA, but the functional significance of this binding remains unknown. In here we report XPO1-dependent nuclear shuttling of HAX-1 and the identification of its nuclear export signals. Moreover, we demonstrated HAX-1 influence on mRNA processing of the bound transcripts and its co-localization with processing bodies

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