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Manu Banadakoppa, Daniel Liebenthal, David E. Nowak, Petri Urvil, Uma Yallampalli, Gerald M. Wilson, Aparna Kishor and Chandra Yallampalli Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr+ Escherichia coli receptor protein decay accelerating factor (DAF or CD55) by nitric oxide FEBS Journal 280

Article first published online: 2 JAN 2013 | DOI: 10.1111/febs.12073

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Nitric oxide (NO) down-regulates Dr+ E. coli binding protein DAF. In this study, we showed that binding of transcription factor Sp1 to NO-response region of DAF gene was inhibited by NO. NO promoted the decay of DAF mRNA by inhibiting the binding of mRNA stabilizing protein HuR to an AU-rich element in the 3′-untranslated region of the DAF gene

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