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Bernard Desbuquois, Nadège Carré and Anne-Françoise Burnol Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins FEBS Journal 280

Article first published online: 2 JAN 2013 | DOI: 10.1111/febs.12080

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Grb10/14 and SH2B1 are SH2 domain containing adapters which associate with insulin/IGF1 receptors and act as negative and positive regulators, respectively, of insulin/IGF1 signaling. Here, we review the molecular determinants of their interaction with receptors and the consequences of their overexpression and depletion in cells and mice, and discuss the potential role of altered adapter gene function in insulin resistance

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