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Rajesh K. Singh, Koichi Mizuno, Christina Wasmeier, Silene T. Wavre-Shapton, Chiara Recchi, Sergio D. Catz, Clare Futter, Tanya Tolmachova, Alistair N. Hume and Miguel C. Seabra Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion The FEBS Journal 280

Version of Record online: 2 JAN 2013 | DOI: 10.1111/febs.12081

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Mediator release by mast cells is critical to inflammatory and allergic responses. We used primary mast cells derived from mutant mice lacking Rab27 GTPases and their effectors to test the role of these proteins in secretion. Our results indicate that Rab27a and Rab27b play opposing roles as negative and positive regulators of exocytosis and suggest that this is achieved by coupling to different downstream effectors

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