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Rafael Moreno-Sánchez, Luz Hernández-Esquivel, Nadia A. Rivero-Segura, Alvaro Marín-Hernández, Jiri Neuzil, Stephen J. Ralph and Sara Rodríguez-Enríquez Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I The FEBS Journal 280

Version of Record online: 7 JAN 2013 | DOI: 10.1111/febs.12086

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The rotenone-insensitive ROS production with succinate was greater than with NAD+-linked substrates in heart and tumor mitochondria, but not in liver mitochondria. The ROS production was enhanced by antimycin, but not by stigmatellin, suggesting that CII is the ROS-producing site. Anticancer drugs that bind to and affect CII increased succinate-driven ROS production in heart and tumor mitochondria, and SMPs

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