E-mail a Wiley Online Library Link

Ryo Uehara, Yasunori Ueda, Dong-Ju You, Yuichi Koga and Shigenori Kanaya Accelerated maturation of Tk-subtilisin by a Leu[RIGHTWARDS ARROW]Promutation at the C-terminus of the propeptide, which reduces the binding of the propeptide to Tk-subtilisin The FEBS Journal 280

Version of Record online: 11 JAN 2013 | DOI: 10.1111/febs.12091

Thumbnail image of graphical abstract

Pro-Tk-subtilisin is autoprocessed at Leu69-Gly70. The mutation of Leu69 to Pro decelerates this autoprocessing but accelerates the degradation of the propeptide, and thereby accelerates the maturation of Pro-Tk-subtilisin to Tk-subtilisin. The mutation affects the conformation of the propeptide. The mutation accelerates the degradation of the propeptide by decreasing the binding ability and inhibitory potency of the propeptide

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field