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Ryo Uehara, Yasunori Ueda, Dong-Ju You, Yuichi Koga and Shigenori Kanaya Accelerated maturation of Tk-subtilisin by a Leu[RIGHTWARDS ARROW]Promutation at the C-terminus of the propeptide, which reduces the binding of the propeptide to Tk-subtilisin The FEBS Journal 280

Version of Record online: 11 JAN 2013 | DOI: 10.1111/febs.12091

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Pro-Tk-subtilisin is autoprocessed at Leu69-Gly70. The mutation of Leu69 to Pro decelerates this autoprocessing but accelerates the degradation of the propeptide, and thereby accelerates the maturation of Pro-Tk-subtilisin to Tk-subtilisin. The mutation affects the conformation of the propeptide. The mutation accelerates the degradation of the propeptide by decreasing the binding ability and inhibitory potency of the propeptide

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