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Bing Fang, Hui Y Guo, Ming Zhang, Lu Jiang and Fa Z Ren The six amino acid antimicrobial peptide bLFcin6 penetrates cells and delivers siRNA The FEBS Journal 280

Article first published online: 24 JAN 2013 | DOI: 10.1111/febs.12093

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bLFcin6, a six-amino acid peptide derived from bovine lactoferricin, was characterized as a cell-penetrating peptide (CPP). bLFcin6 exhibited concentration-dependent uptake and intracellular distribution. The penetrating property of bLFcin6 was similar to that of TAT and better than other short CPPs. bLFcin6 delivered siRNA into cells by forming stable electrostatic complexes, inducing significant knockout activity at both the mRNA and protein level

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