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Constantina Fotinou, Jussi Aittoniemi, Heidi de Wet, Ange Polidori, Bernard Pucci, Mark S. P. Sansom, Catherine Vénien-Bryan and Frances M. Ashcroft Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles The FEBS Journal 280

Version of Record online: 27 JAN 2013 | DOI: 10.1111/febs.12097

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ATP-sensitive potassium (KATP) channels are hetero-octameric complexes that link cell metabolism to membrane electrical activity. It consists of four pore-forming Kir6.2 and four regulatory sulphonylurea receptor (SUR) subunits. Single particle electron microscopy of purified SUR2B shows that SUR2B can form tetramers independently of Kir6.2. Our results provide a first glimpse of how the different domains of SUR may be arranged

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