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Robert C. Bernhards, Anne E. Marsden, Shannon K. Esher, Timothy L. Yahr and Florian D. Schubot Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro The FEBS Journal 280

Version of Record online: 24 JAN 2013 | DOI: 10.1111/febs.12103

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Pseudomonas aeruginosa utilizes a type III secretion system (T3SS) to cause human infection. The T3SS is activated by the transcription factor ExsA which is inhibited by the antiactivator ExsD. Here we demonstrate that ExsD alone is sufficient to inhibit ExsA-dependent transcription in vitro, and a monomeric ExsD variant (ExsDM59R) reveals that the ExsD trimer is involved in thermoregulation

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