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Chunfeng Li, Qi Ba, Aiping Wu, Hong Zhang, Tao Deng and Taijiao Jiang A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly The FEBS Journal 280

Version of Record online: 31 JAN 2013 | DOI: 10.1111/febs.12107

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Interfering with assembly of the Influenza virus polymerase complex could offer novel and effective anti-flu therapeutics. We identified a novel peptide PB1731-757 that can potentially inhibit influenza virus replication by interfering with assembly between PB1c and PB2n. Interestingly, in-depth analyses show that the PB1731-757 interacts with PB1c and hydrophobic residues of PB1c play an essential role in the PB1c-PB1731-757 interaction

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