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Anna Wade, Aaron E. Robinson, Jane R. Engler, Claudia Petritsch, C. David James and Joanna J. Phillips Proteoglycans and their roles in brain cancer The FEBS Journal 280

Version of Record online: 6 FEB 2013 | DOI: 10.1111/febs.12109

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Glioblastoma (GBM) is characterized by abnormal activation of receptor tyrosine kinase signaling pathways and a poor prognosis. In cancer, extracellular proteoglycans help regulate oncogenic signaling and tumor cell invasion via extracellular interactions with ligands, receptors, and extracellular matrix components, and intracellular interactions with enzymes and structural proteins. We propose that proteoglycan alterations promote GBM progression and represent promising therapeutic targets.

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