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Dmitriy Mazurov, Lubov Barbashova and Alexander Filatov Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes The FEBS Journal 280

Version of Record online: 6 FEB 2013 | DOI: 10.1111/febs.12110

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Tetraspanins interact with transmembrane proteins called molecular partners. We describe a new partner of tetraspanin CD9, metalloprotease CD10. Using mutagenic analysis we determine that large extracellular loop and cytoplasmic C-terminus of CD9 are involved in the interaction with CD10. Association of CD10 with CD9 enhances the release of CD10 with exosomes. This may facilitate pre–B cell migration in bone marrow

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